He has also played with the Arizona Coyotes, New York Rangers, Carolina Hurricanes, and Philadelphia Flyers as well as SKA Saint Petersburg in the Kontinental Hockey League (KHL).

Marie Greyhounds in 2015, with whom he won both the Max Kaminsky Trophy for OHL defensemen, and the CHL Defenceman of the Year award.

The Tampa Bay Lightning selected DeAngelo 19th overall in the 2014 NHL Entry Draft, and he signed a three-year, entry-level contract with them later that year.

After one season with their American Hockey League affiliate, the Syracuse Crunch, DeAngelo was traded to the Coyotes, and he made his NHL debut in 2016.

He was again traded, this time to the Rangers, in 2017, and steadily improved his performance until the 2019–20 NHL season was cut short due to the COVID-19 pandemic.

[2] In addition to playing for the Mercer Chiefs of the Atlantic Youth Hockey League, DeAngelo dabbled in baseball and basketball.

[3] DeAngelo was also close to his grandparents, and his paternal grandfather Lou would drive him to and from the local ice rink during his youth hockey career.

In January 2011, he suffered a broken patella while blocking a slapshot in a game against the Des Moines Buccaneers, and the injury kept him out for the rest of the season.

[20] After attending training camp in 2015, DeAngelo was assigned to the Lightning's 2015 American Hockey League (AHL) affiliate, the Syracuse Crunch.

[28] On June 23, 2017, the Coyotes traded DeAngelo, as well as the seventh overall pick in the 2017 NHL Entry Draft, to the New York Rangers in exchange for center Derek Stepan and goaltender Antti Raanta.

[31] DeAngelo suffered a sprained ankle during a match against the Carolina Hurricanes on March 12, and missed the final weeks of the season to recover.

Although DeAngelo also led the team in penalty minutes with 77, coaches and sports journalists noted that he was showing more discretion in when to respond aggressively.

[34] Quinn had a notable intolerance for the outbursts that had characterized the earlier part of DeAngelo's career; the player was a healthy scratch for about 20 games during the season.

[35] DeAngelo was also part of a high-profile incident in which he knocked Kyle Okposo of the Buffalo Sabres unconscious in the third period of a 6–2 Rangers victory.

Salary negotiations dragged into the Rangers' training camp before DeAngelo agreed to a one-year, $925,000 deal on September 20, 2019, less than two weeks before the start of the season.

[44] On July 23, 2021, the Rangers placed DeAngelo on unconditional waivers, allowing the team to buy out the remainder of his contract and releasing him as a free agent.

On October 30, DeAngelo registered his first Gordie Howe hat trick with a goal, an assist, and a fight with Reese Johnson of the Chicago Blackhawks.

[51] On March 8, 2023, the NHL Department of Player Safety issued DeAngelo a two-game suspension for spearing Tampa Bay Lightning forward Corey Perry.

[56] On September 23, 2024, DeAngelo signed a one-year contract with SKA Saint Petersburg of the Kontinental Hockey League (KHL).

[59] On January 24, 2025, having returned to North America as a free agent, DeAngelo was signed to a one-year, league-minimum contract with the New York Islanders for the remainder of the 2024–25 NHL season.

[69] He participated in the tournament again in 2021 alongside fellow NHL players Adam Fox, Joel Farabee and Oliver Wahlstrom.

One of his earliest viral tweets was in response to a graph showing teammate Ryan Strome's shooting percentage, to which DeAngelo responded, "@strome18 has been one of our best players since being traded here last year.

[72][73] After Trump was banned from using Twitter in light of the 2021 United States Capitol attack, DeAngelo announced that he was deactivating his account and joining the conservative social media platform Parler instead.