Sperandeo is notable for frequently playing the roles of tough characters from his native region, Sicily.

As of 2011, he was working on La Nuova Squadra, a police drama televised by Rai Tre, as the Superintendent Salvatore Sciacca.

He also acted in four of the sequels of the popular television drama, "La piovra", which is about the Mafia and had a little role in The Sicilian of Michael Cimino.

He has appeared in many other Italian films, the most notable being La scorta ("The escort") by Ricky Tognazzi, as well as "Boys on the Outside" and "Forever Mary", the latter two set in his home town of Palermo.

In 2001, Sperandeo won the David di Donatello award for Best Supporting Actor in "I cento passi" ("One Hundred Steps"), directed by Marco Tullio Giordana, about the story of Peppino Impastato in which he played the role of Mafia boss Tano Badalamenti.