Toomsuba is a census-designated place (CDP) and unincorporated community in Lauderdale County, Mississippi, United States.

Interstate Highways 20 and 59 run along the southern edge of the community, with access from Exit 165 (Will Garrett Road).

I-20 and I-59 lead west to Meridian and northeast 77 miles (124 km) to Tuscaloosa, Alabama, while U.S. Route 11 and 80 lead west to Meridian and east 9 miles (14 km) to their split near Cuba, Alabama.

[6] In addition to the Toomsuba town center at the crossroads of US 11/80 with Will Garrett Road and Lauderdale–Toomsuba Road, the CDP contains residential development around Bailey Lake, a reservoir just west of the town center.

As of the 2020 United States census, there were 778 people, 300 households, and 194 families residing in the CDP.