[2] Among the most fundamental characteristics of a protein are the N- and C-termini defining the start and end of the polypeptide chain.
[9] TopFIND is a resource for comprehensive coverage of protein N- and C-termini discovered by all available in silico, in vitro as well as in vivo methodologies.
[1] The data is presented to the user with a strong emphasis on the relation to curated background information and underlying evidence that led to the observation of a terminus, its modification or proteolytic cleavage.
All information is accompanied by metadata like its original source, method of identification, confidence measurement or related publication.
A positional cross correlation evaluation matches termini and cleavage sites with protein features (such as amino acid variants) and domains to highlight potential effects and dependencies in a unique way.