It flows to the southeast, on the western slopes of the Lepa Gora mountain, next to the villages of Merćez, Selova, Žuč, Miljeviće and Dankoviće.

Near the mouth are located the city of Kuršumlija and medieval ruins of "Marina kula" (The tower of Mara), and this is where the Toplica region begins.

The central part of the region occupies Toplička (or Prokupačka) kotlina (Depression of Toplica/Prokuplje), between the mountains of Veliki Jastrebac from the north and Sokolovica, Vidojevica and Pasjača from the south, with many smaller settlements on the river: Donje Krmčare, Grabovnica, Bogojeva, Barlovo, Donje Točane, Donji Pločnik, Tulare, Donja Konjuša, Donja Toponica, and the center of the whole region, the city of Prokuplje.

The river continues on the northern slopes of mountain Pasjača, next to the villages of Podina, Voljčince, Badnjevac and the smaller regional center Žitorađa.

Initially, under the leadership of Kosta Vojinoviċ (1890-1917), rebels had some success, liberating many places in the area (at that time, Niški okrug).