The Toplica District (Serbian: Топлички округ, Toplički okrug, pronounced [tǒplit͡ʃkiː ôkruːɡ]) is an administrative district in southern Serbia, named after the river Toplica.

As of the 2022 census, the district has a population of 77,341 inhabitants,[1] making it the smallest district by population in Serbia.

Its administrative center is the city of Prokuplje.

It encompasses the city of Prokuplje and three municipalities: As of the 2022 census, the district has a population of 77,900 inhabitants.

[1] Ethnic composition of the municipality: Note: All official material made by the Government of Serbia is public by law.