She has appeared in made for television films, including A Friend to Die For (1994), A Carol Christmas (2003), The Mistle-Tones (2012), both versions of Mother, May I Sleep with Danger?

She has also starred in several independent films including The House of Yes (1997), Trick (1999), Scary Movie 2 (2001), Cthulhu (2007), Kiss the Bride (2007) and Izzie's Way Home (2016).

Spelling's parents were from Jewish families whose ancestors moved to the United States from Russia and Poland.

Tori Spelling portrayed Donna for the show's entire run and was nominated for two Young Artist Awards.

[9][10] While starring on Beverly Hills, 90210, Spelling was cast in a number of made-for-television films, including Co-ed Call Girl (1996), A Friend to Die For (1994), and Mother, May I Sleep with Danger?

[15] On January 7, 2009, it was reported that Spelling would reprise her role as Donna Martin on Beverly Hills, 90210 spin-off 90210.

"[17] Home Sweet Hollywood's spin-off series, Tori & Dean: sTORIbook Weddings premiered on April 6, 2011.

[18] Writers, who claimed they came up with the idea of a similar series starring Spelling and husband Dean McDermott, filed a $60 million lawsuit against the series, citing breach of implied-in-fact contract, breach of fiduciary duty, slander of title, false advertising, and unfair business practices among other charges.

[23][24] It was announced on August 26, 2013, that production had started on a reality television series titled Tori & Dean: Cabin Fever.

[25] The series chronicles Spelling, McDermott, and their four children as they move to a lakeside cabin in Ontario, Canada while renovating it into their vacation home.

[25] Spelling starred in the short-lived ABC Family TV series Mystery Girls with former 90210 co-star Jennie Garth in 2014.

[31] In November 2020, Spelling began a podcast with Beverly Hills 90210 co-star Jennie Garth titled 9021OMG, where the two re-watch and share memories from their time on the show and chat about their experiences, along with TV and radio personality Sisanie Villaclara.

[34] In July 2005, Spelling was filming the Lifetime TV-movie Mind Over Murder in Ottawa, during which she met actor Dean McDermott, who was then married to actress Mary Jo Eustace.

[45] While Spelling and McDermott's marriage was back on track, the couple once again made headlines in 2016 for owing $39,000 to American Express in unpaid credit card bills.

Candy, who was on good terms with her daughter, told TMZ at the time that she was helping out Spelling and her family financially.

[46] In June 2023, McDermott announced that he and Spelling decided to separate after 18 years together in a now-deleted Instagram post.