The Semliki Wildlife Reserve is a conservation protected area in the Western Region of Uganda with headquarters at Karugutu in Ntoroko District.

[2] Semliki Wildlife Reserve is located in Kabarole and Ntoroko districts, in the Toro sub-region, on the floor of the rift valley, where Lake Albert, the Rwenzori Mountains and the Kijura escarpment create backdrops.

[4] First established in 1926 by the British colonial Government, the reserve is one of the oldest protected areas in Uganda extending from the Kijura escarpment, north to the River Muzizi and Lake Albert to the low Butuku plains in the West.

[6] The dominant vegetation in Semliki is open Acacia-Combretum woodland and grassy savanna, interspersed with patches of Borassus palm forest.

Primates are well represented with black-and-white colobus, olive baboon and red-tailed and vervet monkey all visible in suitable habitats, while a community of perhaps 70 chimpanzees is resident in Mugiri River Forest.