The series was hosted and produced by comedian Daniel Tosh, who provided satirical commentary on online viral video clips, internet memes, social media, trending topics, society, celebrities, stereotypes, and popular culture as a whole.

[7][8] Within 10 weeks of its premiere, Tosh.0 became the second-most-watched cable network show in its time slot among males aged 18–34, a sought-after advertising demographic.

The show was previously renewed for four more seasons, but this decision was reversed as Comedy Central began transitioning away from live action original programming to adult animation.

[7] The video clips are primarily selected by the show's full-time researchers and validated "on a case-by-case basis" by Comedy Central's standards and practices division.

[19] The range of selected clips includes spontaneous cuteness, whimsical performances, romance, accidents, exhibitionism, fetishism, surrealism, stunts, vomit, gore, and other acute bodily harm.

[3][18] Hank Stuever of The Washington Post says the show's decadent tone is formed around the values and maturity of its young adult target audience.

For example, he displayed a video of a man attempting to climb a precariously homemade staircase of milk crates to reach a flagpole, resulting in a great fall with visibly broken bones.

The segment yields various blends of increased cuteness, humiliation, bullying, parody, black comedy, sympathy, or protectiveness in an attempt to explore and redeem the star and the subject matter.

In addition to garnering a reported average of 1,200 monthly death threats,[19] Tosh's ability to call the audience to action has yielded the mass vandalism of the show's own Wikipedia article,[24] and has resulted in traffic that temporarily crashed CelebrityNetWorth.

[7][29] Within 10 weeks of its premiere, Tosh.0 became the second-most-watched cable network show in its time slot among males aged 18–34, a sought-after advertising demographic.

[3][4][5][18] Hank Stuever of The Washington Post initially gave a mostly negative review of the June 4, 2009, debut episode of Tosh.0.

He found Tosh's stage execution to yield a banal, juvenile, and unnecessary "blooper show" serving as a "cheap example of clearinghouse programming" which adds little to a mashup of viral videos but "clutter, buttressed by a lot of stale references".

[33] Five years later, Stuever re-evaluated the show positively as a now long-time fan, and addressed his retrospective regret of his "prematurely dismissive" impression by writing a new review to serve as "a long-delayed Valentine to [his] secret dirty love, Daniel Tosh", and described Tosh.0 as "a TV show about the Internet, literally and thematically", with a hilarious use of cruelty "as black as the online soul, and as fleeting and ephemeral", yielding a "blundering exploration of race, class, gender, life".

He describes the show as "continually playing Steal the Bacon for unexploited scraps against the absorbent blob that is viral culture".