[6][7][8] A gay aspiring actor, Cary, and his sister Brooke, a former professional dancer, try to find their place in the world while wrestling with their feelings about their 13-year-old brother Chase's sudden rise to Internet fame.

Kathie Lee Gifford, Hoda Kotb, Mario Lopez, Tinsley Mortimer, Michael Che, Andy Cohen, Patrick Wilson, Zosia Mamet, Debi Mazar, Ian Ziering, Tavi Gevinson, Jordana Brewster, Alessia Cara, Bowen Yang, Justin Bartha, Leah McSweeney, Dylan O'Brien, Kiernan Shipka, Lukas Gage, Simu Liu, Ben Platt, Cameron Kasky, Edie Falco, and Lawrence O'Donnell also appear as themselves.

After staying overnight at Mackenzie's place, Cary calls Pat and informs her that she doesn't need to fund the movie, as he plans to leave the project altogether.

A few months prior to being named co-head writers for Saturday Night Live's 42nd season, Chris Kelly and Sarah Schneider spent a week in early 2016 developing the premise of The Other Two.

[26] Speaking to Vulture, Schneider said they intentionally wrote the character of Chase to be kind and innocent because it would subvert expectations of the story.

[29] In October 2017, it was announced that Drew Tarver, Heléne Yorke, Case Walker, Ken Marino, and Molly Shannon had joined the cast.

[32] The show's creators Chris Kelly and Sarah Schneider were reportedly the subject of complaints to human resources over their behavior on set and in the writers' room.

The allegations, which became known to the public just before the series finale in June 2023, include Kelly verbally abusing writers and overworking the crew and claims that Schneider enabled his behavior.

[33] The toxic workplace environment was reported to have been an "open secret," with Tina Fey joking at an awards ceremony, "Nobody indulges writers like Lorne Michaels.

The website's critical consensus reads: "With game leads and a wickedly witty sense of humor, The Other Two skewers and celebrates pop culture with equal aplomb.