He began his on-screen career starring in The Cut and EastEnders: E20, later securing a regular role as Neil Cooper in the soap opera Hollyoaks and Ryan Sinclair in Doctor Who.

[6] In 2010, Cole joined the cast of BBC teen drama The Cut, in which he played the role of Noah Achebe, who was introduced in the third series.

[14] The actor went on to appear in a 2013 episode of the BBC medical drama Holby City as Keith Potts.

[8] In 2015, Cole played the characters of Djimon Adomakoh in ITV drama Lewis and Kobina in an episode of historical series Versailles.

[8] That year Cole also had a brief appearance in the film Star Wars: The Force Awakens, as the X-Wing pilot Lt.

[21] In August 2022, Tosin Cole was announced as a lead character alongside an ensemble cast in Netflix's Supacell, directed by Rapman.