[5] Bain's unemployment coincided with the beta release of World of Warcraft: Cataclysm, and he started producing videos of himself talking over gameplay on YouTube, hoping to earn money through the website's ad-revenue system.

[4] In late April 2014, Bain announced he had a precancerous mass in his colon, the first indications of bowel cancer, a condition with which two of his grandparents had also been diagnosed.

[8] By January 2016, Bain had also decided to distance himself from social media, while still focusing on making his game critique videos.

[13] In mid-April 2018, Bain was hospitalised for extreme back pain, from which the doctors discovered that the cancer was growing, applying pressure on his spine.

While he underwent a clinical trial to combat the spread, the doctors found that the cancer had become too resistant to medication and conventional chemotherapy would be ineffective; he was also informed that his liver was failing.

The doctors transferred him to palliative care with the option to resume clinical treatment if a trial compatible with his failing liver became available.

Because of this, knowing he did not have long left to live, Bain announced he was fully retiring from game criticism, believing he was no longer capable of performing his work at a level that would satisfy himself and his fans.

On 7 June 2018, Old School RuneScape developers Jagex added a grave to the game world decorated with a top hat, with the message "He was always there to ask and answer one simple question".

[20] Shortly after, on 9 September 2018, Blizzard Entertainment created a commemorative bundle in honor of Bain, with all sales profits going directly to Genna and their son, Orion.

[21][22] Two years after his death, the video game Doom Eternal features an easter egg of a top hat and a plaque reading "Slay Cancer", referencing Bain.

[23] Bain was posthumously inducted into the ESL Esports Hall of Fame, and is the first non-competitive player to receive the honor.

Bain stated that the name TotalBiscuit was a quote taken from the Terry Pratchett novel Carpe Jugulum: "Besides, thought Agnes, I know for a fact there's people out there called Syphilidae Wilson and Yodel Lightley and Total Biscuit.

series, Bain hosted the "Content Patch" programme (started from 30 October 2012, ended 15 July 2016) in which he addressed gaming news and comments.

[38] In the 2022 r/place social experiment project hosted on Reddit, a recreation of the LUL emoji was constructed in the middle of the canvas as a memorial for Bain.

[53][54][55] He stated that the harassment associated with Gamergate was the result of lone actors who wanted to provoke conflict among the people involved in the controversy.

On 6 April 2017, one day before Bulletstorm: Full Clip Edition was due for release, Gearbox published a list of ultimatums made together with Bain for G2A to accept, or else it would back out of the deal.

[58] The following day, Gearbox Publishing publicly announced that it was ending its cooperation with G2A, due to a lack of response from the company concerning the ultimatums.

[60] In February 2012, Bain announced that he would be sponsoring Team Dignitas player BlinG: "The StarCraft community has given a lot to me and in turn I've had the opportunity to give back with SHOUTcraft Invitational.

"[61] In August 2012, Bain offered to sponsor CranK, formerly a member of team SlayerS, to compete in the MLG Pro Circuit 2012-Summer Championship.