The podcast began with conversational interviews with notable internet personalities such as PewDiePie, Post Malone, and Jake Paul.

[9] The podcast grew alongside Hila Klein's clothing line Teddy Fresh, promoting the brand to the audience which became popular among fans.

The podcast focused on discussing personal experiences, pop culture, internet drama and mental health.

[15] Despite this, Frenemies gained recognition in the podcasting realm and found a place in numerous Top 50 lists,[16][17] frequently pulling in millions of viewers per episode.

[25] In May 2022, the channel was suspended when Ethan joked on air that someone should bomb the National Rifle Association of America (NRA) convention.

Ethan responded later that "[a] few white supremacists successfully lobbied YouTube to suspend me, a Jewish dual citizen of Israel & USA, for antisemitism.