One notable game was "Eat-a-Bug", in which the contestants would stand in front of a chroma key screen and attempt catch with their hands, animated flies, wasps, or ladybugs all the while, trying to avoid giant spiders or bumblebees.

Another episode featured Full House star Candace Cameron visiting a Macy's in New York City to help demonstrate chroma key effects in front of a blue screen.

Total Panic for all intents and purposes, replaced Nick Rocks,[14] which aired on the network from 1984 to 1989, as Nickelodeon's primary outlet to showcase music videos.

Another segment hosted by Greg Lee pitted "Shaking the Tree" by Peter Gabriel and Youssou N'Dour against "Let's Go Round There" by The Darling Buds, for which "Let's Go Around There" wound up winning.

So in effect, just like how Total Panic replaced Nick Rocks as the resident program for music videos on Nickelodeon, it also suddenly became the network's primary outlet for film reviews.

The film review segments on Total Panic actually used the second generation set from Rated K, which was a movie concession stand with a pastel color palette.

Notable guests to appear on Total Panic included news journalist Walter Cronkite, musician "Weird Al" Yankovic[15] and his castmates from the film UHF, Victoria Jackson and Michael Richards, professional wrestler Hulk Hogan, former New York City mayor Ed Koch, comic book writer and artist Walt Simonson,[16] notable pinball player, designer, and promoter Roger Sharpe[17] and illusionist Mark O'Brien.

Also invited for a segment was Andy Eddy,[18] the then editor of VideoGames & Computer Entertainment, to discuss the then new TurboGrafx-16, Sega Genesis, Game Boy, and Atari Lynx consoles.