Totozoquean is a proposed language family of Mesoamerica, originally consisting of two well-established genetic groupings, Totonacan and Mixe–Zoque.

[1] Comparative proto-Totozoquean reconstructions are proposed in Brown et al. (2011) for simple consonants and vowels.

The consonant-inventory for proto-Totozoquean is similar to that reconstructed for proto-Totonacan (Arana Osnaya 1953), and the vowels are not unlike those proposed for proto-Mixe–Zoquean (Wichmann 1995).

A parallel set of laryngealized but otherwise identical proto-Totozoquean vowels is reconstructed for proto-Totozoquean to account for the distribution of laryngealized vowels in the Totonac branch of the Totonacan family, though these left no known trace in proto-Mixe–Zoquean (Wichmann 1995) and there may be a more economical explanation.

Vowel length is likewise an independent parameter reconstructed for proto-Totozoquean that does not seem to affect the correspondences, but in this case it is a feature inherited by both families.