Totsuka Ward is located in eastern Kanagawa Prefecture, and in the center-western area of the city of Yokohama.

There are numerous keyhole tombs from the Kofun period in Totsuka, including one on the grounds of Tomizuka Hachiman Shrine, from which the ward's name is derived.

During the Meiji period the area prospered as a center of meat production to supply the foreign population of nearby Yokohama.

In 1944, the Imperial Japanese Navy established a medical school and large scale hospital facilities in Totsuka.

Totsuka Ward is largely a regional commercial center and bedroom community for central Yokohama and Tokyo.

[1] There are major factories operated by KI Holdings,[2] Hitachi, Nissin Foods, Yamazaki Baking, Pola Cosmetics, and others.