The main remix features Mary J. Blige, Rah Digga, Missy Elliott, Lloyd Banks, Papoose and DMX.

After Busta Rhymes, the other rappers appear in this order: Mary J. Blige in white, Rah Digga in pink, Missy Elliott in purple, Lloyd Banks in blue, Papoose in green and DMX in black (he has his hood up).

Each singer appears with different outfits, such as Busta's white T-shirt, Papoose's, DMX's, Lloyd Banks' jackets, and the ladies' fur coats.

Other cameo appearances in the music video are of Sean Paul, DJ Kayslay, Deelishis, producer Swizz Beatz, Winky Wright, Félix Trinidad, Black Rob and Spliff Star.

At the 2006 BET Awards, Busta performed the Video Remix live on stage, along with will.i.am, Elliott, Banks, Blige, Papoose, and Rah Digga.

The performance also featured a surprise final verse by Eminem, who began with some of Busta's lines from A Tribe Called Quest's "Scenario".

Busta Rhymes' bodyguard and entourage member, Israel "Izzy" Ramirez, was fatally shot outside the set of the music video for "Touch It" during filming in Brooklyn on February 5, 2006.

The video also includes cameos from Brooke Valentine, DJ Kay Slay, Sean Paul, Swizz Beatz, Spliff Star, and boxing champions Félix Trinidad and Winky Wright, who had fought in May 2005.