Known for extensive curation of prominent figures in East Coast hip-hop, his albums were met with success in the regional market; his first two were released by Columbia Records.

[2] As a youth involved in New York's flourishing hip hop scene, Keith witnessed firsthand the ascent of legendary disc jockeys such as Grandmaster Flash, Grand Wizzard Theodore, and Kool DJ Red Alert, in the late 1970s and into the 1980s.

The single's music video includes cameo appearances by Swizz Beatz, N.O.R.E., Raekwon, WC, and Lloyd Banks.

[citation needed] Although the song was not a major success, its music video was aired on MTV Jams and BET.

In 2013, "About That Life" featuring Fabolous, T-Pain, Rick Ross, Nelly, and French Montana was released as a single from Rhyme or Die.

It debuted and peaked at #54 on the Hot R&B/Hip-Hop Songs chart, making it one of Kay Slay's most successful singles to date.

In 2019 DJ Kay Slay Broke Bronx New York Rapper Bruse Wane's hit song Killa Soundboy live on his streets sweepers radio show.

[6][7] In 2021, Dj Kay Slay released the track "Rolling 110 Deep" which featured 110 hip hop artists with contributing verses from Ice-T, Shaq, Coke La Rock, KRS-One, Kool G Rap, Ghostface Killah, Roy Jones Jr, Omar Epps, and others.