The Tour de Nesle (French pronunciation: [tuʁ də nɛl]) was one of the four large guard towers on the old city wall of Paris, constructed at the beginning of the 13th century by Philip II of France and demolished in 1665.

In 1314, a scandal known as the Tour de Nesle affair implicated the daughters-in-law of Philip IV, who were accused of adultery.

Demolished in 1665, mansion and tower became the place of the Collège des Quatre-Nations (later occupied by the Institut de France) with the Bibliothèque Mazarine.

In the 19th century, Alexandre Dumas wrote the celebrated romance La Tour de Nesle (1832), in which he portrayed the place as a theatre of orgy and the place of murder of a Queen of France at the beginning of the 14th century, (likely Margaret of Burgundy).

The story was also the basis of a 1955 film known in English as Tower of Lust (French: La Tour de Nesle).