Tracey Ann Rouault is an American rheumatologist and physician-scientist who researches mammalian iron-sulfur proteins.

[1] IRP1 acquires an iron-sulfur cluster in iron-replete cells that prevents it from binding to IREs, and enables it to function as a cytosolic aconite.

[1] Defective iron sulfur biogenesis causes several diseases, including Friedreich ataxia, and four new diseases that our group helped to discover and characterize, including ISCU myopathy, sideroblastic anemia from GLRX5 deficiency, and lactic acidosis caused by mutations in NFU1 and BOLA3.

[1] The group studies metabolic remodeling that occurs in kidney cancers caused by mutations in fumarate hydratase and succinate dehydrogenase, subunit B.

[1] Rouault's lab discovered that heme oxygenase 1 deficiency causes iron redistribution because lack of heme oxygenase 1 leads to death of erythrophagocytosing macrophages, and the lab is attempting to prevent disease in heme oxygenase deficient mice by performing bone marrow transplants and infusing macrophages exogenously to supply the mice with normal macrophages.