This species was previously within the genus Phrynohyas, which was recently synonymized with Trachycephalus .

Its natural habitats are subtropical or tropical dry forest, subtropical or tropical moist lowland forest, subtropical or tropical moist shrubland, subtropical or tropical dry lowland grassland, rivers, intermittent rivers, freshwater lakes, freshwater marshes, intermittent freshwater marshes, arable land, pastureland, plantations, rural gardens, urban areas, heavily degraded former forest, water storage areas, and ponds.

This frog is one of several other tree frogs in the family Hylidae that secrete a toxic substance from their skin that produces extreme irritation and pain when in contact with mucosal membrane surfaces.

The veined tree frog has been observed being eaten by a mantis.

Symptoms and treatment of acute conjunctivitis caused by ... Retrieved March 27, 2021, from https://www.researchgate.net/publication/269179448_Symptoms_and_Treatment_of_Acute_Conjunctivitis_Caused_by_Skin_Secretions_of_Veined_Tree_Frog_Trachycephalus_Venulosus Wilderness & environmental medicine, 2014, Vol.25 (4), p.486-487