[8] Common side effects include inflammation of the nose and throat.

[8] Serious side effects may include angioedema, pancreatitis, joint pain.

[8] Linagliptin was approved for medical use in the United States,[11] Japan, the European Union, Canada, and Australia in 2011.

[8][12] In 2020, it was the 293rd most commonly prescribed medication in the United States, with more than 1 million prescriptions.

[15] Linagliptin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.