The loop section from the spa through the clinic and the then-under-construction university opened in 1927, operating intactly ever since.

While sharing its track with Line 1 from the main train station to Kálvin square, Line 2 takes a turn to the left and reaches the densely populated housing estates on the west side of the city, Vénkert, Újkert, Sestakert and Doberdó street.

Until 1951, the section was commonly used by both trains and trams, when the Hungarian National Railways shortened the railroad by connecting it into the Debrecen - Nyíregyháza main line.

After 1951 and the local railway's departure from Böszörményi way, DKV inherited every part of the former line inside Debrecen's boundaries.

While technically still connected, the section between Nyulas and the lung clinic never became electrified, and no tram services were offered between them.

Line number 5 was closed in 1973, only a handful of years before the Doberdó street housing estates started to rise on the location of the former Nyulas district.