It was directed and written by series creator Joe Murray, with Carlos Alazraqui providing all voices.

A new version of the pilot, that was extended for the purposes of including it as a regular episode, was produced and released as part of the first season.

It also features an extended end credit sequence to accommodate the names of production crew behind "Trash-O-Madness".

The sun rises over O-Town as Earl, a dog who escaped from a laboratory wakes up, growling and barking crazily, biting off the lid to the trash can he resides in, and drinks weed-killer, and gazes at a house behind him.

Suddenly, he hears a noise and finds a Hill-O-Stench garbage truck driving erratically and crushing someone's car flat.

Downstairs, Rocko puts multiple piles of garbage while Earl sneaks around the house while peeking through the windows occasionally.

Rocko plugs in his vacuum cleaner, the Suck-O-Matic, while Spunky stands in front of the sucking tube.

He opens a container implied to be emergency rations (a sign reads "Buy War Bonds" is on it, only to find a slime ball being what's left in it, disgusting Rocko.

Joe Murray originally wrote "A Sucker for the Suck-O-Matic" as the pilot episode but the executives decided that Heffer Wolfe might be "a little too weird for test audiences."

Murray, instead of removing Heffer from "A Sucker for the Suck-O-Matic," decided to write "Trash-O-Madness" as the pilot episode.

Once the plan fell behind schedule, Murray, Nick Jennings, and George Maestri modified a 35 mm camera to film during the night.