Lupick is best known for his local reporting on the Downtown Eastside neighborhood of Vancouver and how the North American opioid epidemic has disproportionately affected the people who live there.

The reporting has focused on initiatives led by community activists, such as naloxone distribution and unsanctioned overdose prevention sites, and often leads with the voices of people who use drugs.

[2] In 2010, Lupick took a leave of absence from his job at the Georgia Straight and accepted a position with the Canadian nonprofit Journalists for Human Rights in Malawi and then Liberia.

During this time, he freelanced for a variety of local and international publications, primarily writing for The Africa Report, Toronto Star, and Al Jazeera English.

It recounts Vancouver's history with harm reduction, telling a story of grassroots drug user activism and the struggle for North America's first sanctioned supervised injection facility, Insite, which opened in 2003.

Prominent space is given to the voices of Insite's founders, Liz Evans and Mark Townsend, and the cofounders of the Vancouver Area Network of Drug Users (VANDU), Bud Osborn and Ann Livingston.