Travis Strikes Again: No More Heroes received mixed reviews upon release, with critics praising its story and imaginative presentation, while finding the gameplay aspects repetitive.

One of the famous critics "John Miike Heroes" said the game has its own "Knack 2 of morales" such as the way Travis wants to revive Badgirl to initially make out with her in front of her father Badman.

Despite this, gameplay and combat itself predominantly plays out as a hack and slash similar to that of previous No More Heroes titles, occasionally undergoing perspective changes and introducing new gimmicks or minigames that are pertinent to the genre of each individual game.

[4] New to the series is the ability to equip "Skill Chips" (named after Gundam models) that allow the player to utilize an array of special attacks, ranging from a scattergun-type blast to an orbital laser.

Badman justifies his actions as being for the sake of his own survival, as he wishes to get revenge on Travis Touchdown, who had murdered his daughter, Bad Girl, during the events of No More Heroes.

The two form a truce, opting to team up to locate every Death Ball, and defeat all of the games, in order to resurrect Bad Girl.

In his search for the Death Balls, Travis ends up traversing the planet and meeting characters from other Suda51 games, such as Kamui Uehara from The Silver Case, and Mondo Zappa from Killer Is Dead.

She also implemented elements of her history and upbringing into the Death Drive's games, such as basing the in-game serial killer "Doppelganger" on her adoptive father.

Travis learns that the Death Drive MK-II was designed as a machine that would create clones of its users, and that while it was initially intended for space travel, the government had re-purposed it to be a super soldier program — a prospect which caused Juvenile to sabotage the project in an act of defiance, and go into hiding.

Despite this, the mother machine responsible for its protocols still lays dormant within the CIA, and Travis is warned that completing all six Death Ball games will cause it to reboot, allowing the government to continue developing super soldiers.

He interacts with the mother machine and is transported to Mars, where he meets John Winter; the creator of the very original Death Drive and Juvenile's mentor.

Winter explains that he retired to Mars to escape Earth's problems, and safeguards the planet, opposing the government's plans to emigrate there.

In a playable post-credits segment, Travis is controlled from a third person perspective similar to the previous No More Heroes games, set in a default Unreal Engine level.

Travis and Shinobu prepare to battle against his subordinates before they're interrupted by a pair of villainous alien lucha libre wrestlers bent on world domination, and a self-proclaimed super hero named "Notorious".

He manages to beat them in a game of Fire Pro Wrestling, obtaining the location of the completed version of the Killer Marathon Death Ball, which is in the possession of Travis' wife, Sylvia Christel.

[13] One such title is Hyper Light Drifter, with Nintendo of America showcasing Travis's shirt alongside announcing the game's release on the Switch.

[12] The game was formally announced as Travis Strikes Again: No More Heroes in an August 2017 Nintendo Direct, along with further reveals at the PAX West event a few days later.

[9] Suda also stated that Travis Strikes Again serves as "something of a stepping stone on the road to No More Heroes 3", and hopes to make a true sequel if the game proves successful enough.

Kimberly Brooks and Kathryn Fiore were confirmed to return in the roles of Shinobu Jacobs and Bad Girl respectively, while Greg Ellis was cast to play a new boss character, Brian Buster Jr.[27] A PlayStation 4 and Windows version were released on October 17, 2019.