Its inspirational stories of sports and folk heroes, saints, school kids, Catholic living, history, science and similar topics were drawn by artists that included such prominent figures as EC's Reed Crandall, Graham Ingels and Joe Orlando, Marvel Comics' Joe Sinnott, and DC Comics' Murphy Anderson and Jim Mooney.

In 1964, a ten-part serial in Vol 19 #11-20 told the story of a presidential campaign vying for the nomination of fictional Governor of New York Timothy Pettigrew.

Frank Moss, featured the son of a mixed marriage, Catholic and Protestant, and even in its early days casually depicted such relatively daring concepts as racially integrated friendships.

Series contributors after Moss included writer Max Pine and comic strip artists Frank Borth and, in the 1960s, Fran Matera.

[13][14] Others who worked on Treasure Chest included writer-editor Bob Wischmeyer, writers Ruth Barton, Frances E. Crandall, Helen L. Gillum, Arch Ward, and Berry Reece, and artists or writer-artists Wilbur G. Adam, Murphy Anderson, Bernard Baily, James O. Christiansen, Ed Hunter, Graham Ingels, E.A.