The church was erected between 1637 and 1639,[2] in the Moldavian capital, in honour of the Three Holy Hierarchs of Eastern Orthodoxy (Basil of Caesarea, Gregory of Nazianzus, and John Chrysostom), and was blessed by Bishop Varlaam.

In 1640, Prince Vasile Lupu, the renowned defender of the Orthodox Church, set up here the first printing press in Moldavia and the Vasilian College, a higher education institute.

Western architectural elements (Gothic, Renaissance) combine with the Eastern style, of Armenian (Khachkar), Georgian, Persian, Arabian or Ottoman inspiration, in a totally bold conception, whose result is a harmonious ensemble.

[1] The effusive scenery makes the church resemble a shrine of architectonic proportions, especially conceived to protect the Sfânta Cuvioasă Parascheva's relics (1641).

In the gate's tower (which today no longer exists), that served as belfry, Vasile Lupu had installed a huge horologe, the first public use clock in Romanian Principalities (1654).