TiLo (Italian: Treni Regionali Ticino Lombardia) is a limited company established in 2004 as a joint venture between Italian railway company Trenord and Swiss Federal Railways (SBB CFF FFS); both companies participate in the equity of TILO SA with participation of 50%.

Most traveled along the Como ↔ Chiasso ↔ Mendrisio ↔ Lugano ↔ Bellinzona ↔ Biasca (S10) and Bellinzona ↔ Locarno routes (S20), served by trains every 30 minutes (every 15 minutes on average at peak times).

Line S30 Bellinzona ↔ Luino is served every 2 hours, with a single daily train continuing to Busto Arsizio.

The staff that runs the trains in Italy is supplied by Trenord and by Swiss Federal Railways for the trains running in Switzerland.

[citation needed] The TILO fleet consists of the following trainsets.