Trenque Lauquen is a city in the west of the province of Buenos Aires, Argentina, 444 km (276 mi) from Buenos Aires City and 80 km (50 mi) from the border with the province of La Pampa, on the intersection of National Routes 5 and 33.

Trenque Lauquen is the largest city of the district (partido) of the same name, and has a population of about 40,000 inhabitants as per the 2001 census [INDEC].

It was founded on 12 April 1876 by the advancing troops of Colonel Conrado Excelso Villegas, under orders from the Minister of War Adolfo Alsina, as the center of operations of the North Division of the Border Commandancy, during the Conquest of the Desert (the campaign to subject the territories originally occupied by aboriginal tribes to the government of Buenos Aires).

Similar to the rest of the Pampas, Trenque Lauquen has a temperate climate.

This article about a place in Buenos Aires Province, Argentina is a stub.