Lyles was born in Saskatoon, Saskatchewan to an American father and Canadian mother, and moved to Indianapolis, Indiana at the age of seven.

Lyles originally committed to Indiana in September 2010 during his freshman year of high school, but then later decommitted in August 2012.

[3] During his senior year of high school, Lyles averaged 23.7 points, 12.9 rebounds and 3.5 assists and led Arsenal Tech to the IHSAA Class 4A State Championship game with a 63–59 victory over Lake Central.

[12] On February 3, he was named a Rising Stars Challenge participant at the 2016 NBA All-Star Weekend, replacing the injured Nikola Mirotić on the World Team roster.

[19] On February 6, 2020, Lyles had a double-double, scoring a season-high 23 points while grabbing 10 rebounds and two steals in a 125–117 loss against the Portland Trail Blazers.

[20] On February 29, 2020, Lyles scored 20 points, nine rebounds, two assists, four steals, and one block in a 114–113 win over the Orlando Magic.

[24] On February 10, 2022, Lyles and Josh Jackson were acquired by the Sacramento Kings in a four-team trade that sent Marvin Bagley III to the Pistons.

Two days later, the NBA announced that Lyles had been suspended for one game without pay due to his role in the altercation.