The Tri-Valley encompasses the cities of Dublin, Livermore, Pleasanton and San Ramon, the town of Danville, and the CDPs of Alamo, Blackhawk, Camino Tassajara, Diablo, and Norris Canyon.

[1][2] The Ohlone tribe settled the area circa 2000 BC, particularly in the northern part of Pleasanton.

In winter, daytime temperatures reach the 50s and 60s, while nights are in the 30s and 40s, dipping on rare occasions into the 20s.

[6] The Tri-Valley is serviced by WHEELS, operated by the Livermore Amador Valley Transit Authority (LAVTA), a bus agency that operates local bus service throughout Livermore, Pleasanton and Dublin, including service to Hacienda Business Park, Lawrence Livermore National Laboratory, Las Positas College, Stoneridge Mall, the West Dublin/Pleasanton BART Station and the Dublin/Pleasanton BART station.

The Tri-Valley is home to the corporate headquarters of many companies, including 10X Genomics, 24 Hour Fitness, Architectural Glass and Aluminum, Bay Area News Group, Blackhawk Network Holdings, CallidusCloud, Chevron, The Cooper Companies, Discovery Toys, Ellie Mae, GE Digital, Gillig Corporation, Patelco Credit Union, Prosoft Engineering, Ross Stores, SafeAmerica Credit Union, Safeway, Shaklee, TriNet, Veeva Systems, Visioneer, WANdisco, The Wine Group, Product10x Accelerator, Salestable and Workday.

Major employment centers include Bishop Ranch and Hacienda Business Park.