The Tricastin Nuclear Site (Site Nucléaire du Tricastin) is a collection of facilities run by Areva and EDF located on right bank of the Channel of Donzère-Mondragon (diversion canal of the Rhône River) south of the city of Valence (70 km upstream) and north of Avignon (65 km downstream).

The site houses 4 pressurized water reactors (PWR) of 915 MW each, which were built mostly in the 1970s and brought online in the early 80s.

Tests on 2 July 2004 by the Autorité de sûreté nucléaire (Nuclear Safety Authority) found that it would take 37 minutes to respond to a fire.

The regulator Autorité de sûreté nucléaire (ASN) had ordered the temporary shutdown because of the risk of embankment failure in the event of an earthquake.

The liquid that escaped to the ground contained about 75 kg of unenriched uranium which is toxic as a heavy metal while possessing only slight radioactivity.

[12] Additionally, a nuclear waste leak that apparently had remained undiscovered since 2005 spilled into a concrete protective shell in Romans-sur-Isere.

Areva, who owns the site, ensured that the leak had not caused harm to the environment, but the issue sparked discussion[13] about an old French army terrain, where nuclear waste was deposited in shielded dumps.

Acting on the wishes of the wine growers to change the name of the appellation to something without "Tricastin", to avoid being associated with the nuclear power plant, in June 2010, INAO signalled its intention to allow a name change from Coteaux du Tricastin AOC to Grignan-Les Adhemar effective from the 2010 vintage.