She also voiced Sarah Kerrigan in the video game StarCraft II and its expansion packs (2010–2015), and portrayed Charlotte Richards/Goddess in the urban fantasy series Lucifer (2016–2021).

[1] Helfer has walked for top fashion shows, such as Carolina Herrera, Christian Dior, Claude Montana, Givenchy, John Galliano, and Dolce & Gabbana.

She later played a model named Ashleigh James on the May 16, 2002 episode of CSI: Crime Scene Investigation ("The Hunger Artist").

[12] Helfer also played a major role in Electronic Arts' video game Command & Conquer 3: Tiberium Wars, as the high-level Nod general Kilian Qatar, along with her Battlestar Galactica co-star, actress Grace Park.

In 2009, she reprised her role as Number Six in Battlestar Galactica: The Plan – a television movie that tells the story of the series from the Cylons' point of view.

Awards: Nominations: In August 2008, Helfer appeared on the stage of NVISION 08, an event sponsored by NVIDIA, where she discussed her role in Battlestar Galactica as well as the use of computer graphics on the show.

She voices Sarah Kerrigan in StarCraft II: Wings of Liberty and the expansion sets Heart of the Swarm and Legacy of the Void.

[8] Helfer joined the cast of Jerry Bruckheimer's TNT drama, Dark Blue,[17] as FBI Special Agent Alex Rice.

[22] In 2011, Helfer starred as Morgana, a necromancer, in the TV series pilot 17th Precinct from Ron Moore with Galactica's co-stars James Callis and Jamie Bamber.

[26] In 2014, she played Molly Parker on ABC's Killer Women, a remake of the Argentinian drama Mujeres Asesinas, with producer Sofia Vergara.

[8] Also in 2014, she played Viondra Denniger, the steward and captain's wife of the titular starship in the miniseries Ascension on its long journey carrying people to populate a new world.

In 2015, she appeared in the series finale of Falling Skies as the Espheni Queen, the leader of the alien race that had invaded Earth and devastated humanity.

In 2016, Helfer was added to the main cast for the second season of the Fox series Lucifer, playing the vessel of the titular character's real mother and “Goddess of all creation”.

In 2019, she was added to the main cast for the fourth season of the SyFy series Van Helsing, playing Dracula, the Dark One, who is the ruler of the vampire species.