In addition, there was a backlash against the Catholicism of the Spanish and a greater acceptance of Protestant Christianity represented by the Americans.

[14] In 1901 the Evangelical Union was established in the Philippines to co-ordinate activities amongst the Protestant denominations and lay the foundations for an indigenous religious movement.

Episcopalian American missionaries established the St. Luke's Medical Center in 1903 which later the Trinity University of Asia is closely affiliated with.. St. Luke's foundation as a dispensary in 1903 by the Episcopalians as the second Protestant hospital in the Philippines after Iloilo Mission Hospital of Central Philippine University in Iloilo, has made it grow and become one of the reputable and renowned healthcare institutions in the country.

The Trinity University of Asia-St. Luke's College of Nursing, a collegiate and organic unit of the university founded in 1907 as St. Luke's Hospital School of Nursing, is the precursor and oldest academic unit predating Trinity's founding by 56 years.

Trinity College of Quezon City was launched through the bequest of the Procter and Gamble stock of the family of Rt.

Lyman C. Ogilby, then Bishop of the Philippine Episcopal Church, initiated the move to set up a Christian college.

By 1965, the Joint Council of the Church led by Bishop Ogilby of the Philippine Episcopal Church and Bishop Isabelo de los Reyes Jr. of the Iglesia Filipina Independiente approved the transfer of the collegiate courses to the college's present location, the Cathedral Heights compound.

In 2007, Trinity's College of Nursing landed on the 1st spot among the top performing schools in board exams with a 99% passing rate.

[18] In a very recent 2009 report filed by the CHED, Trinity continued to remain as one of the Top 20 Nursing schools in the country by landing in the 3rd spot.