Triple helix

Generally, the identity of a triple helix depends on the type of helices that make it up.

The individual helices are also held together by an extensive network of amide-amide hydrogen bonds formed between the strands, each of which contributes approximately -2 kcal/mol to the overall free energy of the triple helix.

The bonded bases in the center exclude water, so the hydrophobic effect is particularly important in the stabilization of DNA triple helices.

The rigidity of the collagen fibers is an important factor that can withstand most mechanical stress, making it an ideal protein for macromolecular transport and overall structural support throughout the body.

Mapping of genome-wide TFO-TTS pairs by sequencing is a useful way to study the triplex forming DNA in the whole genome using oligo-library.

Some roles include increasing stability, translation, influencing ligand binding, and catalysis.

[9][11] The triple helix at the 3' end of the PAN and MALAT1 long-noncoding RNAs serves to stabilize the RNA by protecting the Poly(A) tail from deadenylation, which subsequently affect their functions in viral pathogenesis and multiple human cancers.

[9][12] Additionally, RNA triple helices can stabilize mRNAs by formation of a poly(A) tail 3'-end binding pocket.

The software starts by enumerating the substrings between TFO and TTS and uses statistical tests to find out significant result compared to the background.