After having been the technical manager of a start-up specializing in computer security and having worked for Partner Soft S.A in Paris, he joined the Netscape Communications Corporation where he held various positions from 1997 to 2003, first running product marketing in Southern Europe and then acting as a Technology Evangelist, managing developer relations in Europe.

Tristan Nitot also helped to launch the OpenWeb.eu.org project in 2002, aiming at promoting Web standards and accessibility.

In May 2005, he became an employee of Mozilla Europe, the European home of the Firefox Web browser.

[1] His blog, mostly dedicated to the promotion of open source software, reaches an average of 12,000 readers daily.

[3] On 4 June 2018, Qwant announced that Tristan Nitot has joined their team as Vice-president Advocacy focused on Open Source and privacy.