A trade paperback collecting the five issues was originally scheduled to be published on 18 February 2004, but canceled when Epic was shut down after Bill Jemas, who had been a driving force behind the imprint, resigned as president of Marvel Comics.

Soon they make friends with fellow service staff members Richard and his brother Ben, and the four of them begin hanging out.

Once May gives birth to her healthy baby boy, Peter, Mary takes him to Richie, and they start a family, while May returns home to her parents as if nothing had happened.

These covers were to appeal to a female audience (Marvel originally hoped for high sales outside the comic scene, particularly with a collected edition that was to be heavily promoted in many bookstores, but never published after the series did not do well in the direct market).

The second printing of the first issue (Trouble #1: The Second Chances Edition) was the only one to feature a conventional comic book cover, drawn by Frank Cho.

[1] The reveal that series' main characters, May, Ben, Mary and Richard, are meant to be Peter Parker's Aunt May and Uncle Ben, and his parents Richard and Mary Parker, and thus, the revelation that the Ultimate Marvel incarnation of Aunt May is actually Peter Parker's biological mother was seen as highly controversial among Spider-Man fans, with many criticisms of the series mistakenly implying the series to be set in Marvel's primary continuity,[2][3][4] with Millar's dialogue being criticized as not being representative of the time it is set in (supposedly the 1970s)[5] and his storytelling failing to grab the audience; many complained that the characters were written too similarly, and were hard to keep apart, "save for the fact that one of the girls will do it on the first date when the other one won't".