As an amateur, he won a bronze medal at both the 2017 World Championships and 2019 Pan American Games.

[2] Isley made his professional debut on February 13, scoring a unanimous decision (UD) victory against Bryant Costello.

[3] On January 15, 2022 Isley faced Harry Keenan Cruz Cubano on the undercard of Joe Smith Jr. vs Steve Geffrard at the Turning Stone Resort Casino in Verona, New York.

[4] On March 2, 2024 Isley defeated Marcos Hernandez by TKO in the seventh round in Verona, New York.

[5][6] Isley defeated old amateur rival Javier Martínez at Fontainebleau Las Vegas on June 21, 2024.