The arena has also hosted various combat sport events, including mixed martial arts (MMA), boxing, and professional wrestling.

MMA promoter Ultimate Fighting Championship (UFC) signed a long-term tenancy agreement with T-Mobile Arena in 2017, under which it agreed to host four events per-year over the next seven years.

[4] Caesars Entertainment had previously envisioned using the location to build a baseball park, but the company's buyout by Harrah's cancelled the plans.

Through the following year, Harrah's became uncertain on continuing with the project, not knowing if AEG would split the costs, and whether building a major league-ready stadium without a guaranteed franchise to play on it would be feasible given the enduring financial crisis.

[5] The original plans were to break ground in June 2008 and finish the arena in 2010, but by 2009, it was revealed that the stalled project had not even done a traffic study despite being located near a busy intersection.

[9] Plans were further fleshed out over the following months with the announcement of a $100-million pedestrian shopping area, The Park, to serve as a gateway to the arena,[10] and the retention of prominent sports architecture firm Populous to design the project.

[18][19] The arena held its grand opening on April 6, 2016, with a concert by Las Vegas natives The Killers, Shamir and Wayne Newton.

[21] In 2016, the National Hockey League awarded an expansion team to a Las Vegas ownership group led by Bill Foley, with T-Mobile Arena as its home venue.

[24][25][26] The expansion bid was approved and announced by the NHL on June 22, 2016; the new team, the Vegas Golden Knights, began play in the 2017–18 season.

[38] All Elite Wrestling (AEW) made its debut at the arena with Double or Nothing in 2022, which was the promotion's first event to exceed $1 million in gate revenue.