He played in Major League Baseball (MLB) for the Houston Astros, Baltimore Orioles and San Diego Padres.

In 2007, Patton played in Minor League Baseball for the Corpus Christi Hooks and Round Rock Express.

Patton was part of a trade package sent by the Astros to the Baltimore Orioles on December 12, 2007, in return for shortstop Miguel Tejada.

In the 2012 season, Patton made the team out of spring training and was used effectively out of the bullpen all year, mainly as a left handed specialist due to his sweeping side-arm pitching motion.

Patton sprained his previously injured ankle while walking through a parking garage, and would go on the disabled list for approximately one month.