His mother moved from Puerto Rico to go to college at Missouri Southern State University in Joplin and his father followed shortly after.

[1] He was a three-year varsity football player for the Webb City High School Cardinals, during the 2013 through 2015 seasons as an offensive lineman.

Due to his success as a true freshman, Colon started 13 games the following year, making it onto the Southeastern Conference coaches' All-Freshman squad.

[10] He was promoted to the active roster on October 12, 2020, and made his first career start against the Pittsburgh Steelers on December 2, 2020, due in part to the Ravens' team-wide COVID-19 outbreak.

[13] The Ravens' announcement of this signing officially referred to him as Trystan Colon for the first time, per his request, and has remained the case since.