[5] Jones played in 13 games and made eight starts as a true freshman at East Carolina in 2013.

[11] Jones was also named as one of three finalists for the 2016 Biletnikoff Award, which is given annually to the nation's outstanding receiver in college football.

[12] Jones received an invitation to the Senior Bowl and had practiced well during the week leading up to the game.

He led both teams and greatly improved his draft stock after making six receptions for 68 receiving yards and a touchdown for the North, who lost 16–15 to the South.

Jones also participated at East Carolina's Pro Day, but opted to only run positional drills for team representatives and scouts.

The majority of NFL draft experts and analysts projected Jones to be selected in the second round.

[22] On September 17, 2017, in Week 2, he barely missed on a potential game-winning pass from quarterback Tyrod Taylor on fourth down late in the game of a 9–3 loss to the Carolina Panthers.

[25][26] Following his rookie season, Jones revealed he had played much of the year with a torn labrum in the shoulder, which required offseason surgery.

He caught a 57-yard pass from rookie quarterback Josh Allen in Week 2 against the Los Angeles Chargers that was his new personal record for his longest reception.

[28] Jones recorded his first touchdown of the season against the Houston Texans, a 16-yard pass from Nathan Peterman (who entered the game after Allen was injured), that briefly gave the Bills the lead.

[40] Against the Baltimore Ravens in Week 1, Jones recorded a 31-yard touchdown to end the game as the Raiders won 33–27 in overtime.

[49] On August 23, 2024, Jones was suspended five games for violating NFL's personal conduct policy.