The Tsalenjikha Cathedral Church of the Transfiguration of Savior (Georgian: წალენჯიხის მაცხოვრის ფერისცვალების საკათედრო ტაძარი, romanized: ts'alenjikhis matskhovris peristsvalebis sak'atedro t'adzari) is a medieval Georgian Orthodox cathedral at the town of Tsalenjikha, Samegrelo-Zemo Svaneti region, Georgia.

[1] Built in the 12th-14th centuries, the Tsalenjikha Cathedral is a central cross-domed church with a narthex and three arcaded galleries two of which, that to the south and north, had been converted into the familial chapel of the House of Dadiani.

A bilingual Greco-Georgian inscription on the south-western pillar reveals that the interior of the church was frescoed by Cyrus Emanuel Eugenicus, a Byzantine artist from Constantinople, recruited by Vameq I Dadiani (r. 1384–1396), a high-ranking official at the royal court of Georgia.

A Georgian inscription on the north-western pillar mentions two other persons – Makharobeli Kvabalia and Andronike Gabisulava – sent by Vameq to bring the Greek master to Georgia.

In the 17th century, old frescoes were repaired at the behest of Bishop Eudemon Jaiani, while Levan II Dadiani, Prince of Mingrelia (r. 1611–1657), commissioned the adjoining chapel and had its interior covered with murals.