He was automatically disqualified from the National Assembly after missing two consecutive sessions because of his self-imposed exile to South Africa.

[2][3] Khama was elected to the National Assembly in Serowe North West in a 2008 by-election as a Botswana Democratic Party (BDP) member.

From 2012 until 2018 he was Minister of Environment, Conservation, Natural Resources and Tourism.

In 2018, President Mokgweetsi Masisi made him Minister of Youth Empowerment, Sports and Culture Development.

[4] Prior to the 2019 general elections, he left the BDP to join the new Botswana Patriotic Front (BPF),[5] and was one of three BPF candidates elected.