Tsuzuki Ward is located in eastern Kanagawa Prefecture, and north of the geographic center of the city of Yokohama.

During the Edo period, it was a rural region classified as tenryō territory controlled directly by the Tokugawa shogunate, but administered through various hatamoto.

The core of the Kōhoku New Town became a significant commercial centre once the subway line extension between Shin-Yokohama and Azamino was completed in 1993.

Tsuzuki Ward is primarily a regional commercial center and bedroom community for central Yokohama, Kawasaki and Tokyo.

Car Make T&E and Weld X Overdose Techniques Factory are headquartered in Tsuzuki Ward.