There are regular buses (numbers 12, 13, 15, 18, 62, 68 and variants thereof) providing services to the city centre, as well as to Aigburth, Bootle, Croxteth, Huyton and Old Swan and Stockbridge village.

The area is bisected by the A5049 West Derby Road, an east/west arterial route out of Liverpool city centre.

The bridge, carrying the Canada Dock Branch over West Derby Road, used to accommodate Tue Brook railway station until 1948.

The Merseytram System (Line 1) was scheduled to run through Tuebrook prior to the abandonment of the project when funding from the Government was denied.

It was announced in December 2019 that Liverpool City Council had commissioned a feasibility study to consider reopening the Canada Dock Branch to passenger traffic.