As of 2014–2015, it is the largest enrolled public high school in the state of Mississippi.

The school offers a curriculum containing 160 Carnegie units, 24 of which are Advanced Placement.

[4] The school's boundary includes the vast majority of Tupelo and a portion of Saltillo.

The segregated schools alternated nights using Robins Field for football games.

[7] As of 2022- 2023, Tupelo High School offers extracurricular activities, including football, slowpitch and fastpitch softball, cross country, volleyball, swimming, basketball, soccer, bowling, archery, baseball, wrestling, golf, tennis, cheer, and track and field.