Saltillo is a city in Lee County, Mississippi, United States.

As of the 2020 United States Census, there were 4,922 people, 1,839 households, and 1,151 families residing in the city.

As of the census[6] of 2000, there were 3,393 people, 1,361 households, and 974 families residing in the town.

There were 1,453 housing units at an average density of 166.8 per square mile (64.4/km2).

25.6% of all households were made up of individuals, and 8.4% had someone living alone who was 65 years of age or older.