Tupelo Regional Airport (IATA: TUP[2], ICAO: KTUP, FAA LID: TUP) is a public use airport located 3.7 miles; 3.2 nautical miles (6 km) west of the central business district of Tupelo, a city in Lee County, Mississippi, United States.

Many college football teams visiting the University of Mississippi (Ole Miss), 49 miles west in Oxford, fly into Tupelo.

In 2012, after Delta Connection had ceased serving Tupelo, Silver Airways began service to Greenville, Muscle Shoals, and Atlanta using Saab 340s.

Since April 2016, Contour has upgraded their service several times including replacing their twin turboprop BAe Jetstream 31 aircraft with Embraer ERJ 135 regional jets.

[1] For the 12-month period ending December 31, 2011, the airport had 50,916 aircraft operations, an average of 139 per day: 56% general aviation, 38% military, 6% air taxi, and <1% scheduled commercial.

[19] Contour Airlines began daily nonstop flights in 2016 to Nashville using British Aerospace Jetstream 31 turboprop aircraft.